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21+ RUO Research use only — not for human or veterinary use. Not medical advice.

Library · Tripeptide

KPV

The tripeptide lysine–proline–valine, a C-terminal fragment of alpha-melanocyte-stimulating hormone. It is studied mainly in cell and mouse models of intestinal inflammation.

Entry reviewed

This entry summarises published research. It is not guidance on use, and research-grade material is not for human or veterinary use.

What it is

KPV is a three-amino-acid peptide corresponding to the end of alpha-melanocyte-stimulating hormone (α-MSH). At about 342 g/mol it is one of the smallest compounds in research-peptide catalogues.

What has been studied

A 2008 study reported that intestinal cells take KPV up through the PepT1 transporter, and described its effects in mouse models of colitis. Later work builds on this cell and animal research.

Reading supplier listings

KPV also appears as a component of blends. For a blend, a certificate should report how much of each component the vial contains, not one overall purity figure.

Regulatory status

Research vendors supply it as a laboratory reagent. None of the sources cited here describes it as an approved medicine, and we have not searched national registers for it. Confirm registration status with the authority in your country (see the country regulations pages).

Known limitations of the evidence

  • Evidence comes from cell and rodent models.
  • The small size of the molecule makes identity testing by mass spectrometry essential, because many contaminants are of similar mass.

References

  1. Animal study Dalmasso G, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology, 2008 (opens an external site in a new tab) link checked 2 Oct 2026
  2. Chemical database Lys-Pro-Val (KPV) — PubChem CID 125672 (opens an external site in a new tab) link checked 2 Oct 2026